Brian Bigger

Brian Bigger is Professor of Advanced Therapeutics at the Institute for Regeneration and Repair, University of Edinburgh. Brian set up his independent research group at the University of Manchester in 2006 to understand the pathology of and develop treatments for neurological lysosomal storage disorders, a group of devastating childhood dementias. Here, the team defined roles for lysosomal storage and neuroinflammation in the pathology of neurological lysosomal diseases and developed several gene and cell therapy treatments for lysosomal diseases, three of which have now progressed to clinical trial. Brian was a co-founder of Orchard Therapeutics and past Chairman of the European Study Group for Lysosomal Diseases.  In 2023, Brian moved to the University of Edinburgh where his research group continues to focus on developing innovative gene and cell therapies for neurological diseases, including childhood dementias, and bringing these treatments to patients.

Advances in new treatments for genetic brain diseases

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